Group Leader:
Nic Jones
I obtained my BSc in Microbiology at University College London in 1971 before completing a PhD at the University of Edinburgh in 1974 focusing on the link between DNA replication and cell division. My first post-doctoral position took me to the United States and the University of Conneticut Medical school studying bacterial cell division, before moving to set up my own research laboratory in 1978 at Purdue University, Indiana, studying how DNA tumour viruses affect cell proliferation and growth, and key genes involved in viral-mediated transformation of normal cells to cancer cells.
I returned to the UK in 1985 to join the Imperial Cancer Research Fund in London and joined the Paterson Institute in 1999 as Director and Group Leader of the Insititute’s Cell Regulation Laboratory. I am also Director of the MCRC, established when the Insititute became part of the University of Manchester in 2006, in collaboration with The Christie and Cancer Research UK.
Postdoctoral Fellows
Yujun Di
Clare Lawrence
Associate Scientists
Wolfgang Breitwieser
Caroline Wilkinson
Graduate Students
Malgorzata Gozdecka
Orestis Mavroudis-Chocholis
Jacek Walczynski
Scientific Officers
Keren Dawson
Steve Lyons
Cell Regulation Group - Publications 2000 - 2009
Udagawa T, Nemoto N, Wilkinson CR, Narashimhan J, Jiang L, Watt S, Zook A, Jones N, Wek RC, Bähler J, Asano K. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 map kinase-dependent stress response in fission yeast. (2008) J Biol Chem. May 23.
Bhoumik A, Fichtman B, Derossi C, Breitwieser W, Kluger HM, Davis S, Subtil A, Meltzer P, Krajewski S, Jones N, Ronai Z. Suppressor role of activating transcription factor 2 (ATF2) in skin cancer. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1674-9. Epub 2008 Jan 28.
Chen D, Wilkinson CR, Watt S, Penkett CJ, Toone WM, Jones N, Bähler J. Multiple pathways differentially regulate global oxidative stress responses in fission yeast. (2008) Mol Biol Cell.Jan;19(1):308-17.
Dawson K, Toone WM, Jones N, Wilkinson CR. Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombe. (2008) Eukaryot Cell. Jun;7(6):926-37.
Reiter W, Watt S, Dawson K, Lawrence CL, Bähler J, Jones N, Wilkinson CR. Fission yeast MAP kinase Sty1 is recruited to stress-induced genes.(2008) J Biol Chem. Apr 11;283(15):9945-56.
Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N. Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82.
Bruhat, A., Cherasse, Y., Maurin, A.C., Breitwieser, W., Parry, L., Deval, C., Jones, N., Jousse, C. and Fafournoux, P. (2007) ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation. Nucleic Acids Res, 35, 1312-1321.
Lawrence, C.L., Maekawa, H., Worthington, J.L., Reiter, W., Wilkinson, C.R. and Jones, N. (2007) Regulation of Schizosaccharomyces pombe Atf1 protein levels by Sty1-mediated phosphorylation and heterodimerization with Pcr1. J Biol Chem, 282, 5160-5170.
Sinclair, J., Weeks, M., Butt, A., Worthington, J.L., Akpan, A., Jones, N., Waterfield, M., Allanand, D. and Timms, J.F. (2006) Proteomic response of Schizosaccharomyces pombe to static and oscillating extremely low-frequency electromagnetic fields. Proteomics, 6, 4755-4764.
Weeks, M.E., Sinclair, J., Butt, A., Chung, Y.L., Worthington, J.L., Wilkinson, C.R., Griffiths, J., Jones, N., Waterfield, M.D. and Timms, J.F. (2006) A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe. Proteomics, 6, 2772-2796.
Thornton G, Wilkinson CR, Toone WM, Jones N. (2005) A novel pathway determining multidrug sensitivity in Schizosaccharomyces pombe. Genes Cells . 10 , 941-951.
Bhoumik A, Takahashi S, Breitwieser W, Shiloh Y, Jones N, Ronai Z. (2005) ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
Mol Cell. 18 , 577-587.
Maehara K, Yamakoshi K, Ohtani N, Kubo Y, Takahashi A, Arase S, Jones N, Hara E. (2005) Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53. J Cell Biol. 14 , 553-560.
Harrison C, Katayama S, Dhut S, Chen D, Jones N, Bahler J, Toda T. (2005) SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast. EMBO J. 24 , 599-610.
Verschuren EW, Jones N, Evan GI. (2004) The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. J Gen Virol. 85 , 1347-61. Review.
Wilkinson CR. (2004) Ubiquitin-like proteins: meet the family. Semin Cell Dev Biol. 15 , 199-200.
Vivancos AP, Castillo EA, Jones N, Ayte J, Hidalgo E. (2004) Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration.
Mol Microbiol. 52 ,1427-1435.
Bhoumik A, Jones N, Ronai Z. (2004) Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity.
Proc Natl Acad Sci U S A. 101 , 4222-4227.
Wilkinson CR, Dittmar GA, Ohi MD, Uetz P, Jones N, Finley D. (2004) Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Curr Biol. 14 , 2283-2288.
Verschuren EW, Hodgson JG, Gray JW, Kogan S, Jones N, Evan GI. (2004) The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res. 64 , 581-589.
Castillo EA, Vivancos AP, Jones N, Ayte J, Hidalgo E. (2003) Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1. J Biol Chem. 278 , 40565-40572.
Chen D, Toone WM, Mata J, Lyne R, Burns G, Kivinen K, Brazma A, Jones N, Bahler J. (2003) Global transcriptional responses of fission yeast to environmental stress. Mol Biol Cell , 14 , 214-229.
Greenall A, Hadcroft AP, Malakasi P, Jones N, Morgan BA, Hoffman CS, Whitehall SK. (2002) Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress. Mol Biol Cell. 13 , 2977-2989.
Verschuren EW, Klefstrom J, Evan GI, Jones NJ. (2002) The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. Cancer Cell , 2 , 229-241.
Veal, EA, Toone, WM, Jones N, Morgan BA. (2002) Distinct roles for glutathione S-transferase in the oxidative stress response in Schizosaccharomyces pombe. J Biol Chem , 277 , 35523-35531
Smith DA, Toone WM, Murchie , DC , Bahler J, Jones N, Morgan BA, Quinn J. (2002) The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast. J Biol Chem , 277 , 33411-33421.
Quinn, J, Findlay VJ, Dawson K, Millar JB, Jones N, Morgan BA, Toone WM. (2002) Distinct Regulatory Proteins Control the Graded Transcriptional Response to Increasing H(2)O(2) Levels in Fission Yeast Schizosaccharomyces pombe. Mol Biol Cell , 13 , 805-16.
Castillo EA, Ayte J, Chiva C, Moldon A, Carrascal M, Abian J, Jones N, Hidalgo E. (2002) Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues. Mol Microbiol. 45 , 243-254.
Wilkinson CR (2002) New tricks for ubiquitin and friends. Trends Cell Biol. 12 , 545-546.
Pereira PS, Jones NC. (2001) The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating. Genes Cells , 6 , 789-802.
Laman H, Peters G, Jones N. (2001) Cyclin-mediated export of human Orc1. Exp Cell Res , 271 , 230-237.
Laman H, Coverley D, Krude T, Laskey R, Jones N. (2001) Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication. Mol Cell Biol , 21 , 624-635.
Hagan IM, Jones N, Carr AM. (2001) New insights into development from mitosis of a unicellular yeast. Dev Cell. 1 , 158-160.