Group Leader:
Angeliki Malliri
I completed my under graduate degree in Biology in the University of Patras in Greece and obtained my PhD from the University of Crete, Greece. I then worked as a post-doctoral scientist in the laboratory of Professor Brad Ozanne in the Beatson Institute for Cancer Research in Glasgow and in the laboratory of Dr John Collard in the Cell Biology Division of the Netherlands Cancer Institute in Amsterdam, The Netherlands, where I was funded by a Marie Curie European Fellowship. In 2004, I joined the Paterson Institute for Cancer Research as a Junior Group Leader.
Postdoctoral Fellows
Sonia Castillo-Lluva
Helen Rushton
Simon Woodcock
Scientific Officer
Gavin White
Graduate Students
Lucy Dalton
Natalie Reeves
Chong Tan
Cell Signalling Group
Tumour initiation and progression result from inappropriate activation of intracellular signalling cascades. Rho-like GTPases are molecular switches in signalling pathways that regulate cytoskeletal and junctional organisation, as well as gene transcription. In this way, Rho proteins influence cell morphology, adhesion, motility, as well as cell cycle progression and cell survival. Rho proteins are transforming in vitro and are essential for Ras-mediated in vitro transformation. Moreover, data has emerged to directly implicate Rho proteins in tumour initiation and progression in vivo. Our group investigates how the activities of certain regulators of the Rho protein Rac are controlled. We are also identifying signalling events downstream of Rac that modulate tumour susceptibility and disease progression