Group Leader:
Angeliki Malliri
I completed my under graduate degree in Biology in the University of Patras in Greece and obtained my PhD from the University of Crete, Greece. I then worked as a post-doctoral scientist in the laboratory of Professor Brad Ozanne in the Beatson Institute for Cancer Research in Glasgow and in the laboratory of Dr John Collard in the Cell Biology Division of the Netherlands Cancer Institute in Amsterdam, The Netherlands, where I was funded by a Marie Curie European Fellowship. In 2004, I joined the Paterson Institute for Cancer Research as a Junior Group Leader.
Postdoctoral Fellows
Sonia Castillo-Lluva
Helen Rushton
Simon Woodcock
Scientific Officer
Gavin White
Graduate Students
Lucy Dalton
Natalie Reeves
Chong Tan
Cell Signalling Group Publications - 2000 - 2007
Woodcock SA, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton AD, Gorgoulis VG and Malliri A. (2009) Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1. Molecular Cell 33, 639–653.
Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, Hurlstone AF, Clevers H, Collard JG. (2006) The Rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem., 281, 543-8.
Malliri A, van Es S, Huveneers S and Collard JG. (2004) The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions. J Biol Chem., 279, 30092-30098.
Malliri A. and Collard JG. (2003) Role of Rho-family proteins in cell-adhesion and cancer. Curr Opin Cell Biol. 15, 583-589.
Malliri A, van der Kammen RA, Clark K, van der Valk M, Michiels F and Collard JG. (2002) Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature, 417, 867-871.
Malliri A, ten Klooster JP, Olivio C and Collard JG. (2002) Determination of the activity of Rho-like GTPases in cells. Methods Mol Biol.,189, 99-109.
Stapleton G, Malliri A and Ozanne BW. (2002) Downregulated AP-1 activity is associated with inhibition of Protein-Kinase-C-dependent CD44 and ezrin localisation and upregulation of PKC theta in A431 cells. J Cell Sci., 115, 2713-2724.
Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG and Der CJ. (2002) Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol., 4, 621-625.
Evers EE, Zondag GC, Malliri A, Price LS, ten Klooster JP, van der Kammen RA and Collard JG. (2000) Rho family proteins in cell adhesion and cell migration. Eur J Cancer, 36, 1269-1274.