Applied Computational Biology and Bioinformatics Group
Group Leader: Crispin Miller
The group collaborates with clinicians and basic scientists on the analysis of bioinformatics data. We develop our own tools, databases and algorithms to support these analyses.
www.paterson.man.ac.uk/bioinformatics

Carcinogenesis Group
Group Leader: Geoff Margison
The group's objectives are to establish the role of DNA damage and repair in the biological effects of specific genotoxic agents with the view to exploiting this in the treatment and prevention of cancer.
www.paterson.man.ac.uk/carcinogenesis

Cell Cycle Group
Group Leader: Karim Labib
Our group studies chromosome replication and cytokinesis in eukaryotic cells. We identified a number of novel cell cycle proteins in a systematic analysis of all the essential budding yeast proteins that were previously of unknown function.
www.paterson.man.ac.uk/cellcycle

Cell Division Group
Group Leader: Iain Hagan
The Cell Division group studies cell polarity and stress responses alongside a core interest in how cells take the decision to divide and physically segregate chromosomes into two daughter cells
www.paterson.man.ac.uk/celldivision

Cell Regulation Group
Group Leader: Nic Jones
Our group studies the nature and regulation of stress response pathways and their role in development, tumourigenesis and the protection of cells from environmental damage.
www.paterson.man.ac.uk/cellregulation

Cell Signalling Group
Group Leader: Angeliki Malliri
Our group’s focus is on identifying signalling events downstream of Rho proteins that modulate tumour susceptibility and disease progression.
www.paterson.man.ac.uk/cellsignalling

Clinical and Experimental Pharmacology Group (CEP)
Group Leaders: Caroline Dive / Malcolm Ranson
CEP incorporates teams in pre-clinical drug target validation and biomarker discovery. Within the recently refurbished, specialised PACCAR Good Clinical Laboratory Practice laboratory CEP also develop, validate and implement pharmacokinetic (PK) and pharmacodynamic (PD) assays for Phase I trials.
www.paterson.man.ac.uk/cep

DNA Damage Response Group
Group Leader: Ivan Ahel
Our lab is utilising biochemical and cell-based assays to study mammalian DNA damage response pathways, which should lead to better understanding of the mechanisms underlying human disease and provide a basis for development of new therapies
www.paterson.man.ac.uk/dnadamage

Immunology Group
Group Leader: Peter Stern
Our aim is to translate knowledge of human papillomavirus (HPV) driven carcinogenesis or the expression and function of 5T4 oncofoetal antigen, or other tumour associated molecules, into novel cancer immunotherapy.
www.paterson.man.ac.uk/immunology

Inositide Group
Group Leader: Nullin Divecha
Our group focuses on the function of phosphoinositides in cancer.  Specifically we are interested in how phosphoinositides are spatially and temporally controlled and how they can regulate cancer relevant cellular pathways.
www.paterson.man.ac.uk/inositide

Leukaemia Biology
Group Leader: Tim Somervaille
Our group aims to improve on current treatments for human haematological malignancies such as leukaemia though a more detailed understanding of the biology of both leukaemia stem cells and their normal haematopoietic stem cell counterparts.
www.paterson.man.ac.uk/leukaemia

Stem Cell Biology Group
Group Leader: Georges Lacaud
Our goals are to further define the role of Runx1 and MOZ in early haematopoietic development and how alterations of their function leads to leukemogenesis.
www.paterson.man.ac.uk/stemcellbiology

Stem Cell Haematopoiesis Group
Group Leader: Valerie Kouskoff
Our aim is to identify the cascades of gene expression that regulate either initial hemangioblast formation or its subsequent decisions to differentiate.
www.paterson.man.ac.uk/sch

Stromal-Tumour Interaction Group
Group Leader: Akira Orimo
Our laboratory is focusing on myofibroblasts, which are a hallmark of activated fibroblasts.
www.paterson.man.ac.uk/stromal